Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

1453835-43-2

C32H23ClN2O4

534.99

LLP-3

DMF:PBS(pH7.2) (1:2):0.3 mg/mL
DMSO:2 mg/mL
DMF:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years