Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.

TP2135

C126H202N42O40S2

3009.36

cAC 253

H2O:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years