产品描述
ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) (IC50: 76 uM). ITX3 inhibits TrioN-stimulated RhoG exchange in vitro.
体外活性
TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose-dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].
Cas No.
347323-96-0
分子式
C22H17N3OS
分子量
371.46
别名
ITX3
储存和溶解度
DMSO:2 mg/mL (5.38 mM),ultrasonic and warming and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years