KRAS inhibitor-17 (compound 3-9) 是一种有效的KRAS G12C抑制剂，IC50为 3.37 μM。KRAS inhibitor-17 在 MIA PaCA-2，A549 细胞中的显示 p-ERK 抑制活性，IC50s 分别为 9.25，>33.3 μM。KRAS inhibitor-17 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC 50 of 3.37 μM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC 50 s of 9.25, >33.3 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers [1].

2230873-65-9

C21H18Cl2FN3O2S

466.36

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years