KRAS G12C inhibitor 44 (compound 54) 是一种有效且具有口服活性的KRAS G12C抑制剂。KRAS G12C inhibitor 44 在 MIA PaCA-2、H358 细胞中显示出抗增殖活性，IC50s 分别为 0.016，0.028 μM。KRAS G12C inhibitor 44 在体内显示出抗肿瘤作用。

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC 50 s of 0.016, 0.028 μM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo [1].

C31H36ClFN6O2

579.11

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years