MELK-8a (NVS-MELK8a) 是一种高效的选择性母体胚胎亮氨酸拉链激酶 (MELK) 抑制剂，IC50为 2 nM。MELK-8a 还抑制 FLT3 (ITD)、Haspin、PDGFRα，IC50分别为 0.18、0.19 和 0.42 μM。 MELK 在调节癌细胞的细胞有丝分裂中发挥着重要作用。

MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase ( MELK ) inhibitor with IC 50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC 50 s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells [1].

1922153-17-0

C25H32N6O

432.56

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years