Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]

1135688-47-9

C28H39FN4O10

610.63

Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone;Z-AEVD-FMK;Z-AEVD-FMK

DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years