SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.

in vitro,SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF with IC50 of 8.3 and 10.0 nM, respectively[1].

Significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days caused by SCH 42495 (30 mg/kg; oral gavage; twice daily). Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2]. SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].

145841-10-7

C20H29NO4S2

411.58

SCH 42495 (racemate);SCH 42495 racemate

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years