Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

2320953-89-5

C22H28N4O2.2HCl

453.41

GSK 591 dihydrochloride

H2O:45.34 mg/mL(100 mM)
DMSO:45.34 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years