Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP).

Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), fibrosis (TIMP-1 and MMP-2), and lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2).

209789-08-2

C16H30CaO5

342.48

PD-72953 calcium;Gemcabene calcium

H2O:10 mg/mL (29.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years