Ipamorelin 2acetate(170851-70-4(free base)) 是一种生长激素释放肽，可诱导大鼠纵向骨生长。

Ipamorelin 2acetate is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.

In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).?A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor[1]

In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml).?In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma.?Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma)[1].

T7809L

C38H49N9O5.2C5H10O2

916.12

NNC-26-0161;Ipamorelin 2acetate(170851-70-4(free base))

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years