UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) >100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line.

1186653-73-5

C19H14F3N3O4

405.33

UK122;UK122 TFA salt;uPA Inhibitor II;K122 trifloroacetic acid;UK-122;UK 122;UK-122 TFA salt

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years