Azumolene 是一种 Dantrolene 的类似物,是一种肌肉松弛剂,可用于恶性高热研究。它是一种 ryanodine 受体调节剂,并通过 ryanodine 受体抑制钙释放。
产品描述
Azumolene
体内活性
1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.?2.?The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.?This dose of EU4093 reduces the amplitude of the twitch to 31.9% of the control value.?By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.?3.?The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by EU4093.?4.?The most significant difference between the effect of EU4093 and dantrolene sodium on the contraction of intrafusal muscle was that EU4093 had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.
Cas No.
64748-79-4
分子式
C13H9BrN4O3
分子量
349.144
别名
EU4093 free base;阿珠莫林;Azumolene
储存和溶解度
DMSO:13.89 mg/mL (39.78 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years