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Azumolene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azumolene图片
CAS NO:64748-79-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
EU4093 free base
阿珠莫林
产品介绍
Azumolene 是一种 Dantrolene 的类似物,是一种肌肉松弛剂,可用于恶性高热研究。它是一种 ryanodine 受体调节剂,并通过 ryanodine 受体抑制钙释放。

产品描述

Azumolene

体内活性

1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.?2.?The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.?This dose of EU4093 reduces the amplitude of the twitch to 31.9% of the control value.?By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.?3.?The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by EU4093.?4.?The most significant difference between the effect of EU4093 and dantrolene sodium on the contraction of intrafusal muscle was that EU4093 had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.

Cas No.

64748-79-4

分子式

C13H9BrN4O3

分子量

349.144

别名

EU4093 free base;阿珠莫林;Azumolene

储存和溶解度

DMSO:13.89 mg/mL (39.78 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years