Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).

D-Melinamide is found to be a more effective inhibitor than L-Melinamide. DL-Melinamide suppresses acyl CoA: cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA: cholesterol acyltransferase [2].

Melinamide induces a substantial decrease in the enhanced intestinal ACAT activity in diabetic rats but does not affect intestinal cholesterol esterase activity. Melinamide is a new hypocholesterolaemic drug. A marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurs concomitantly with the drug treatment[3].

14417-88-0

C26H41NO

383.61

甲亚油酰胺;DL-N-(α-Methylbenzyl)linoleamide;AC 223;Melinamide

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years