S07-2010 是一种有效的泛AKR1C(醛缩酮还原酶家族 1 成员 C) 抑制剂，其对AKR1C3、AKR1C4、AKR1C1和AKR1C2的IC50分别为 0.19、0.36、0.47 和 0.73 μM。S07-2010 可诱导 A549/DDP 细胞Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis)。S07-2010 增强了化疗药物对耐药细胞的细胞毒性。S07-2010 对耐药细胞增殖有明显抑制作用。

S07-2010 is a potent pan- AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC 50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells [1].

S07-2010 (0-25 μM, 48h) exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC 50 values of 127.5 and 5.51 μM, respectively [1].

1223194-71-5

C19H21N3O3S

371.46

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years