Uridine triphosphate 是一种核苷酸，调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。

Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.

Incubation of PANC-1 cells with UTP or MRS2768, a selective P2Y2 receptor agonist, resulted in a dose- and time-dependent increase of proliferation.?The messenger RNA transcript and protein of P2Y2 receptor were expressed in PANC-1 cells.?P2 receptor antagonist suramin and small interfering RNA against P2Y2 receptor significantly decreased the proliferative effect of UTP and MRS2768.?Activation of P2Y2 receptor by UTP transduced to phospholipase C, inositol 1,4,5-triphosphate (IP3), and protein kinase C. Uridine triphosphate-induced proliferation was mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increased phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[1].

Proliferation was measured by immunoassay for bromodeoxyuridine incorporation into the pancreatic cell line PANC-1. Effect of UTP was assayed using selective P2 agonist and antagonist, small interfering RNA, intracellular signal inhibitors, and Western blot[1].

63-39-8

C9H15N2O15P3

484.139

三磷酸尿苷;Uridine 5'-triphosphate;UTP;尿苷5'-三磷酸酯;Uridine triphosphate

H2O:150 mg/mL (309.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years