15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

210978-26-0

C21H34O5

366.49

15(R)-15-methyl Prostaglandin D2;15(R)-15-methyl Prostaglandin D2

Ethanol:>75 mg/mL (from PGD2)
PBS (pH 7.2):>5 mg/mL (from PGD2)
DMF:>100 mg/mL (from PGD2)
DMSO:>50 mg/mL (from PGD2)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years