Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.

398138-28-8

C22H37NO5

395.53

Prostaglandin D2 Ethanolamide;Prostaglandin D2 Ethanolamide

DMSO:8.3 mg/mL
DMF:8.3 mg/mL
Ethanol:12.5 mg/mL
PBS (pH 7.2):2.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years