ML359 是选择性可逆的蛋白质二硫键异构酶有效抑制剂(IC50:250 nM)。它对体内血栓形成具有抑制作用。

ML359 is a protein disulfide isomerase inhibitor.

ML359 shown to be a specific inhibitor of PDI.?ML359 shows no cytotoxicity in three human cell lines, and some activity in inhibiting platelet aggregation in vitro.?ML359 will provide more understanding of the mechanisms of PDI in platelet functions.?It also could lead to the development of a new class of antithrombotics that could establish PDI as suitable drug target.

1069858-99-6

C23H28ClNO4

417.93

ML 359;ML-359;ML359

DMSO:84 mg/mL (200.99 mM)
Ethanol:84 mg/mL (200.99 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years