Steroid sulfatase/17β-HSD1-IN-3 (compound 19) 是一种类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 双重抑制剂。Steroid sulfatase/17β-HSD1-IN-3 不可逆地抑制 hSTS 的活性，其IC50值为 27 nM。Steroid sulfatase/17β-HSD1-IN-3 可用于子宫内膜异位症及其他雌激素依赖性疾病的研究。

Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase ( STS ) and 17β-hydroxysteroid dehydrogenase type 1 ( 17β HSD1 ). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with an IC 50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases [1].

Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC 50 value of 27 nM and acts on irreversible inhibition of hSTS with an IC 50 value of 29 nM in T47D human breast cancer cells [1]. Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (20 μM, 48 h) inhibits HEK-293 cells growth by 30% at a concentration of 20 μM with low cytotoxicity [1].

C19H17ClN2O5S

420.87

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years