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Estradiol 3-sulfamate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estradiol 3-sulfamate图片
CAS NO:172377-52-5
包装:25 mg
市场价:10957元

产品名称
雌二醇 3-氨基磺酸
E2MATE
BLE 00084
ES-J 995
产品介绍

产品描述

.Estradiol 3-sulfamate inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor.

体外活性

Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity.

体内活性

Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors.

Cas No.

172377-52-5

分子式

C18H25NO4S

分子量

351.46

别名

雌二醇 3-氨基磺酸;E2MATE;BLE 00084;ES-J 995;Estradiol 3-sulfamate

储存和溶解度

DMSO:62.5 mg/mL (177.83 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years