Antitrypanosal agent 5 (Compound 25) 是一种选择性的抗锥虫剂，对T. brucei和 HEK293 细胞生长的IC50分别为 1 nM 和 483.3 μM。

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC 50 s of 1 nM and 483.3 μM against T. brucei cell growth and HEK293 cells growth, respectively [1].

After dosing T. brucei cells with Antitrypanosomal agent 5 (Compound 25; 200-1000 nM) for 12 hours, Western blot analyses shows Antitrypanosomal agent 5 inhibits tubulin polymerization in T. brucei cells [1]. Western Blot Analysis Cell Line: T. brucei cells [1] Concentration: 200nM; 500 nM; 1000 nM Incubation Time: 12 hours Result: Polymerized tubulin in T. brucei cells was significantly decreased with the treatment of Antitrypanosomal agent 5 at 500 nM and 1000 nM.

C30H30N6O4S

570.66

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years