KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。
产品描述
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.
体外活性
In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain[1].
Cas No.
796874-99-2
分子式
C20H25N3O2
分子量
339.439
别名
KYP-2047
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years