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Talarozole(R enantiomer)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Talarozole(R enantiomer)图片
CAS NO:870093-23-5
包装:5 mg
市场价:9850元

产品名称
Talarozole R enantiomer
(R)-Talarozole
Talarozole (R enantiomer)
产品介绍

产品描述

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid.

体外活性

Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1, and CYP26B1 dose-dependently, and decreased the expression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed the upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2].

体内活性

Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate, or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].

Cas No.

870093-23-5

分子式

C21H23N5S

分子量

377.51

别名

Talarozole R enantiomer;(R)-Talarozole;Talarozole (R enantiomer)

储存和溶解度

DMSO:51 mg/mL (135.10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years