Minocycline hydrochloride是四环素抗生素，具有出色的吸收和组织渗透性，可用于多种细菌感染以及痤疮的治疗。米诺环素可导致在开始治疗后 1 至 3 个月内发生的急性肝炎样综合征或通常在长期治疗后具有自身免疫特征的更隐匿的慢性肝炎。

Minocycline is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.

Minocycline在脑缺血、创伤性脑损伤、亨廷顿舞蹈病和帕金森氏症模型中具有显着的神经保护作用.Minocycline的神经保护作用可能包含它对5-脂氧合酶（一个与大脑衰老相关的炎症酶）的抑制作用.Minocycline的作用与抑制蛋白质合成相关.

Minocycline抑制线粒体中渗透性转换介导的细胞色素c的释放。Minocycline介导的对细胞色素c释放的抑制在体内、细胞中以及离体线粒体中都已得到证明。Minocycline能够抑制caspase-1和caspase-3,一氧化氮合成酶和p38丝裂原活化蛋白激酶的诱导型的活性。实验性局部缺血后,minocycline抑制caspase-1和诱导型一氧化氮合酶的上调,并减少梗塞面积。

13614-98-7

C23H28ClN3O7

493.94

盐酸米诺环素;美满霉素;Minocycline HCl;Minocycline hydrochloride

H2O:12.4 mg/mL (25 mM)
DMSO:49.4 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years