Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 μg/ml, respectively) through cell cycle arrest and apoptosis.

71117-97-0

C38H50O6

602.8

Isogarcinol

Ethanol:20 mg/mL
DMF:25 mg/mL
DMSO:PBS (pH 7.2) (1:10):0.1 mg/mL
DMSO:25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years