KRAS inhibitor-13 (compound 5-6) 是一种有效的KRAS G12C抑制剂，IC50为 0.883 μM。KRAS inhibitor-13 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC50s 分别为 5.9，>100 μM。 KRAS inhibitor-13具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC 50 of 0.883 μM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC 50 s of 5.9, >100 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers [1].

2230873-96-6

C25H19ClFN3O2S

479.95

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years