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6-Hydroxybenzbromarone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
6-Hydroxybenzbromarone图片
CAS NO:152831-00-0
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品介绍

产品描述

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.

体外活性

6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows an over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory effects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.

细胞实验

Cell Line: HUVEC cells. Concentration: 7.5 μM. Incubation Time: 72 hours

Cas No.

152831-00-0

分子式

C17H12Br2O4

分子量

440.08

别名

6-Hydroxybenzbromarone

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years