(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

90780-52-2

C22H32O3

344.49

(±)17-HDHA

0.1 M Na2CO3:2 mg/mL
Ethanol:Miscible
DMSO:Miscible
PBS (pH 7.2):0.8 mg/mL
DMF:Miscible
Powder: -20°C for 3 years
In solvent: -80°C for 2 years