TES-1025 是一种有效且特异性的人 α-氨基-β-羧基粘康酸-ε-半醛脱羧酶 (ACMSD, IC50 = 13 nM) 抑制剂。

TES-1025 is an effective and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (IC50: 13 nM).

TES-1025 increases NAD+ levels in cellular systems[1].

TES-1025 (0.5 mg/kg; i.v.) shows low blood clearance, with low volumes of distribution and half-lives of about 5.33 h, although the blood concentration of TES-1025 (5 mg/kg) is quantifiable for up to 8 h after oral administration. A good systemic exposure is recorded for TES-1025, with a Cmax of 2570 ng/mL reaches at 2 h. The greater oral exposure of TES-1025 is AUC0-8h of 19 200 hong/mL and 36 600 hong/mL, respectively[1].

1883602-21-8

C18H13N3O3S2

383.44

TES-1025

DMSO:95 mg/mL (247.76 mM),Need warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years