Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]

38620-77-8

C35H58O10

638.83

Filipin II

Ethanol:Soluble
DMF:Soluble
Methanol:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years