Rosuvastatin Sodium 是一种竞争性HMG-CoA还原酶 (HMGCR) 抑制剂，IC50为11 nM。Rosuvastatin Sodium 有效阻断HERG电流，IC50为 195 nM。Rosuvastatin Sodium 降低成熟 HERG 的表达以及热休克蛋白 70 (HSP70) 与 HERG 蛋白的相互作用。Rosuvastatin Sodium 有效降低低密度脂蛋白 (LDL) 胆固醇，甘油三酯和 C- 反应蛋白水平。

Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC 50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC 50 of 195 nM [2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels [1] [2] [3].

Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms [2]. Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin [4].

147098-18-8

C22H27FN3NaO6S

503.52

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years