Ravuconazole 是一种口服的三唑广谱抗真菌剂。

Ravuconazole is a potent triazole antifungal that potently inhibits a wide range of fungi.

The in vitro activity of BMS-207147 against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method.?Geometric mean MICs (in microg/ml) were as follows: 1.71 for BMS-207147, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of concentrations of each drug was 0.125 to >16 microg/ml.?Aspergillus fumigatus was significantly more susceptible to BMS-207147 (P< 0.?05) than A. terreus and A. flavus.?No BMS-207147-resistant A. fumigatus isolates were identified, though eight itraconazole-resistant (MIC, >8 microg/ml) isolates were.?BMS-207147 is active against Aspergillus spp. at slightly high concentrations compared with itraconazole and amphotericin B[1].

182760-06-1

C22H17F2N5OS

437.47

雷夫康唑;立福康唑;ER-30346;BMS-207147;Ravuconazole

DMSO:50 mg/mL (114.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years