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4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside图片
CAS NO:229644-17-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品介绍

产品描述

4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis.

Cas No.

229644-17-1

分子式

C32H48O8S

分子量

592.78

别名

4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside

储存和溶解度

DMSO:30 mg/mL
DMF:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years