hCAIX-IN-12 是一种有效的hCAIX抑制剂，对 CAIX 和 CAII 的IC50值分别为 0.74 和 10.78 μM。hCAIX-IN-12 具有抗增殖作用并诱导细胞Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis)。hCAIX-IN-12 增加ROS的产生。hCAIX-IN-12具有研究结直肠癌（CRC）的潜力。

hCAIX-IN-12 is a potent hCAIX inhibitor with IC 50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1].

hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC 50 s of 6.0 μM for HCT-116 cells [1]. hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions [1]. hCAIX-IN-12 (0-50 μM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells [1]. hCAIX-IN-12 (6.0 μM; 48 h) induces apoptosis in HCT-116 cells [1]. hCAIX-IN-12 (6.0 μM; 24,48 h) increases in the levels of ROS in HCT-116 cells [1]. hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase [1]. hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA [1].

2414598-85-7

C18H14N4O3S2

398.46

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years