Mardepodect hydrochloride can cross the blood-brain barrier. Mardepodect hydrochloride is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). It has >1000-fold selectivity over other PDEs.

Mardepodect is active (ED50: 1 mg/kg), in the conditioned avoidance response assay. Administration of Mardepodect to mice induces a dose-dependent increase in striatal cGMP[2].

T16498

C25H21ClN4O

428.91

PF-2545920 hydrochloride;Mardepodect hydrochloride;Mardepodect hydrochloride (898562-94-2 free base)

DMSO:25 mg/mL (58.29 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years