Tylosin 是一种兽医用大环内酯类抗生素,是Streptomyces fradiae的产物。它对革兰氏阳性菌具有高抗菌活性。它是饲料添加剂用于促进动物生长。它被用于治疗家禽、猪和牛的细菌性痢疾和呼吸道疾病。
产品描述
Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.
体内活性
A 25 microliter volume of a 1-% L-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes[1]. Epinephrine is a direct-acting sympathomimetic α-adrenergic and β-adrenergic agonist with cyclic adenosine monophosphate-mediated, complex, bidirectional pharmacologic effects on many target organs[2]. In young adult rats, endogenous release of epinephrine facilitates stable memory formation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[3]. Epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increases arterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects[4].
Cas No.
1401-69-0
分子式
C46H77NO17
分子量
916.112
别名
Tylosin A;Tylosine;Fradizine;泰乐菌素;Tylocine;Tylosin
储存和溶解度
DMSO:91 mg/mL(99.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years