MPO-IN-5 (化合物 1) 是一种有效的、不可逆的MPO(髓过氧化物酶)抑制剂。MPO-IN-5 抑制MPO过氧化作用和hERG结合，IC50值分别为 0.22 和 2.8 μM。MPO-IN-5 表现出快速的抑制动力学，酶失活率 (kinact/Ki) 为 23000 M 1s 1。

MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC 50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (k inact /K i ) of 23000 M 1 s 1 [1].

2476764-11-9

C24H24N6O2

428.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years