XRK3F2 可以抑制p62 (Sequestosome-1)-ZZ结构域的信号传导。

XRK3F2 is a p62 (Sequestosome-1)-ZZ/ domain inhibitor.

The presence of XRK3F2 during MM-preOB co-cultures prevents Runx2 suppression at both d0 and d4. Moreover, XRK3F2 blocks MM-induced upregulation of Gfi1. XRK3F2 blocks the induction of Gfi1 mRNA in BMSC in both treatment conditions. In contrast, XRK3F2 prevents both MM1.S CM and TNFα plus IL7-mediated Runx2 suppression. Further, the pro-inflammatory and myeloma pro-survival factor IL6 mRNA is also reduced by XRK3F2 treatment. In addition, XRK3F2 also prevents TNFα-mediated upregulation of Gfi1 and rescues inhibition of Runx2 in MC4 preOB. XRK3F2 prevents MM-induced GFI1 occupancy at the Runx2 -P1 promoter. XRK3F2 treatment significantly rescues the H3K9ac levels at Runx2 in MM patient hBMSC and XRK3F2 can rescue early steps in osteogenesis [1].

2375193-43-2

C23H24ClF2NO3

435.89

XRK3F2

DMSO:150 mg/mL (344.12 mM),Need ultrasonic
H2O:0.91 mg/mL (2.09 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years