PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.

2143896-83-5

C14H23ClN4O2S2

378.94

PKUMDL-LC-101-D04;PKUMDL-LC-101-D04

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years