您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > UNC7467
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
UNC7467
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UNC7467图片
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
UNC7467 是一种有效的IP6K抑制剂,IP6K2、IP6K1 和 IP6K6 的IC50值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平,而不会显着干扰其他肌醇磷酸盐的水平。UNC7467 可用于肥胖研究。

产品描述

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1].

体外活性

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces inositol pyrophosphates levels. UNC7467 reduces 5-InsP 7 levels by 81% and 5-InsP 8 levels by 63% [1].

体内活性

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) improved diet-induced obesity, insulin resistance, and hepatic steatosis [1]. UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUC last (6054 h ng/mL for intra venous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose [1]. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake. Animal Model: Diet-induced obesity (DIO) mice [1] Dosage: 5 mg/kg (Pharmacokinetic Analysis) Administration: Intravenous injection and intraperitoneal injection Result: 1.19 route iv ip Dose (mg/kg) 5 5 AUC last (h*ng/mL) 6054 2527 CL (mL/min/kg) 13.7

Cas No.

T60164

分子式

C20H13NO3

分子量

315.32

别名

UNC7467

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years