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Amiodarone HCl(NSC 85442)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amiodarone HCl(NSC 85442)图片
CAS NO:19774-82-4
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)681.77
FormulaC25H29I2NO3.HCl
CAS No.19774-82-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 23 mg/mL (33.7 mM)
Water: <1 mg/mL
Ethanol: 11 mg/mL (16.1 mM)
Other info

Chemical Name: 2-Butyl-3-benzofuryl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride

InChi Key: ITPDYQOUSLNIHG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

SMILES Code: O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.[H]Cl

Synonyms

NSC 85442; Amiodarone hydrochloride; NSC-85442; NSC85442;

实验参考方法
In Vitro

In vitro activity: Amiodarone possesses an inhibitory effect on the fast sodium channel as well as on the slow calcium channel. Amiodarone also has non-competitive antisympathetic effects, and modulates thyroid function and phospholipid metabolism. Amiodarone penetrates deeply into the lipid matrix of the membrane, and is released from cardiac tissues very slowly when washed out. Amiodarone (44–88 μM) depresses Vmax of guinea pig papillary muscle without affecting the resting membrane potential, and that this Vmax inhibition is enhanced in a frequency- or use-dependent manner like Class I antiarrhythmic drugs. Amiodarone (50–88 μM) is also found to suppress the depolarization-induced spontaneous action potentials (abnormal automaticity) in ventricular muscles and in Purkinje fibers.

In VivoAmiodarone (1.25–25 mg/kg) results in a decrease in sinus rate, a prolongation of effective and functional refractory periods of the atrioventricular node, and a frequency-dependent conduction delay in the atrioventricular node and in the ventricle of anesthetized dogs. Amiodarone (50 mg/kg/day, i.p. for 3–4 weeks) results in significant decreases in the current density of iK and ito in ventricular cells without affecting iCa and iK1 densities in rabbit. Amiodarone (AM) inhibits intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5′-deiodination (5′DI) without affecting intracellular conversion from T4 to reverse T3 (rT3).
Animal modelRabbits
Formulation & Dosage50 mg/kg/day, i.p.
References

Cardiovasc Res. 1997 Jul;35(1):13-29.