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(E)-5-(2-Bromovinyl)uracil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E)-5-(2-Bromovinyl)uracil图片
CAS NO:69304-49-0
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

Cas No.

69304-49-0

分子式

C6H5BrN2O2

分子量

217.02

别名

(E)-5-(2-Bromovinyl)uracil

储存和溶解度

DMF:60 mg/mL
PBS (pH 7.2):8 mg/mL
Ethanol:0.8 mg/mL
DMSO:53 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years