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GNE-617 hydrochloride(1362154-70-8 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GNE-617 hydrochloride(1362154-70-8 free base)图片
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议

产品名称
GNE-617 hydrochloride
GNE-617 hydrochloride (1362154-70-8 free base)
产品介绍

产品描述

GNE-617 hydrochloride is a potent and competitive inhibitor of nicotinamide phosphoribosyltransferase (IC50: 5nM). GNE-617 hydrochloride reduces the NAD levels in a >95% reduction in both NAPRT1-deficient and NAPRT1-proficient cell lines and exerts (EC50: 0.54nM to 4.69nM).

体外活性

In the in-vitro ADME assessments, GNE-617 hydrochloride shows the most optimal combination of in vitro metabolic stability, MDCK permeability, and protein binding. Besides that, GNE-617 hydrochloride has potent antiproliferation effects on various cell lines. The IC50 values of it in U251, HT1080, PC3, MiaPaCa2 and HCT116 cell lines are 1.8nM, 2.1nM, 2.7nM, 7.4nM and 2nM, respectively.

体内活性

GNE-617 hydrochloride also shows significant antitumor effects on U251 human glioblastoma tumor xenografts in mice and has no obvious effect on body weight loss [1][2].

Cas No.

T22801

分子式

C21H16ClF2N3O3S

分子量

463.88

别名

GNE-617 hydrochloride;GNE-617 hydrochloride (1362154-70-8 free base)

储存和溶解度

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years