C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.

189894-80-2

C24H47NO3

397.63

C6 L-threo Ceramide (d18:1/6:0);C6 L-threo Ceramide (d18:1/6:0)

DMF:5 mg/mL
Ethanol:Soluble
Chloroform:Soluble
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years