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Eliglustat hemitartrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Eliglustat hemitartrate图片
CAS NO:928659-70-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
依利格鲁司特酒石酸盐
Genz-112638
Eliglustat Tartrate
产品介绍
Eliglustat hemitartrate是一种高效的、特异性的、有口服活性的葡糖脑苷脂合成酶抑制剂(IC50:24 nM)。

产品描述

Eliglustat Hemitartrate, with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.

体外活性

Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme.

体内活性

A novel inhibitor of glucosylceramide synthase (Genz-112638) and assessed its activity in a murine model of Gaucher disease (D409V/null).?Biochemical characterization of Genz-112638 showed good potency (IC(50) approximately 24nM) and specificity against the target enzyme.?Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals.?Treatment of older mice that already displayed significant amounts of tissue glucosylceramide (7 months old) resulted in arrest of further accumulation of the substrate and appearance of additional Gaucher cells in affected organs.?These data indicate that substrate inhibition therapy with Genz-112638 represents a viable alternate approach to enzyme therapy to treat the visceral pathology in Gaucher disease.

Cas No.

928659-70-5

分子式

C27H42N2O10

分子量

554.63

别名

依利格鲁司特酒石酸盐;Genz-112638;Eliglustat tartrate;Eliglustat hemitartrate

储存和溶解度

DMSO:50 mg/mL (52.13 mM)
H2O:50 mg/mL (52.13 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years