PG 34 是一种弱的O-GlcNAc转移酶 (OGT) 抑制剂 (IC50=68 μM)，也是OSMI-1 的结构类似物。

PG 34 is a weak O-GlcNAc transferase ( OGT ) inhibitor ( IC 50 =68 μM), and a close structural analog of OSMI-1 [1].

PG34 (0.5-50 μM; 24 h) shows no detectable inhibition of OGT in CHO cells, displays no effect on apoptotic signaling, and shows a moderate effect on cell viability only at the highest concentration [1]. Cell Viability Assay [1] Cell Line: CHO cells Concentration: 0.5-50 μM Incubation Time: 24 hours Result: Inhibited cell growth moderately at 50 μM. Western Blot Analysis [1] Cell Line: CHO cells Concentration: 10, 25, and 50 μM Incubation Time: 24 hours Result: Showed no reduction in global O-GlcNAcylation in cells.

1681056-62-1

C28H25N3O5S2

547.65

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years