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FGTI-2734 mesylate(1247018-19-4 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FGTI-2734 mesylate(1247018-19-4 free base)图片
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
FGTI-2734 mesylate
FGTI-2734 mesylate (1247018-19-4 free base)
产品介绍

产品描述

FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively.

体外活性

FGTI-2734 mesylate (3-30 μM;?72 hours) inhibits both protein prenylation of HDJ2, RAP1A, KRAS and NRAS. FGTI-2734 mesylate (1-30 μM; 72 hours) induces apoptosis in mutant KRAS-dependent, but not mutant KRAS- independent, human cancer cells. ??FGTI-2734 inhibits KRAS membrane localization in RAS-transformed murine NIH3T3 cells and in mutant KRAS human cancer cells.

体内活性

FGTI-2734 mesylate (intraperitoneally;?100 mg/kg/day for 18 to 25 days) only inhibits tumor growth in mutant KRAS-dependent tumors but not in mutant KRAS-independent tumors.

Cas No.

T11282L

分子式

C27H35FN6O5S2

分子量

606.73

别名

FGTI-2734 mesylate;FGTI-2734 mesylate (1247018-19-4 free base)

储存和溶解度

DMSO:75 mg/mL (123.61 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years