IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).

IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24.IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains.

T11597L

C32H43ClN4O8S

679.22

IACS-9571 Hydrochloride;ASIS-P040 Hydrochloride;IACS-9571 Hydrochloride (1800477-30-8 free base)

DMSO:125 mg/mL (184.03 mM),Need ultrasonic and warming
H2O:10 mg/mL (14.72 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years