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Tazemetostat trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tazemetostat trihydrochloride图片
CAS NO:1403255-00-4
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
EPZ-6438 trihydrochloride
E-7438 trihydrochloride
产品介绍

产品描述

Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).

体外活性

Tazemetostat inhibits multi wild-type and mutant lymphoma cell lines proliferation (IC50s: 0.49 nM-7.6 μM).

体内活性

Tazemetostat (250 or 500 mg/kg twice daily for 21-28 days) almost removes the fast-growing G401 tumors.

Cas No.

1403255-00-4

分子式

C34H47Cl3N4O4

分子量

682.12

别名

EPZ-6438 trihydrochloride;E-7438 trihydrochloride;Tazemetostat trihydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years